Updating the natural history of hpv and anogenital cancer

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Natural history studies show that HPV with normal cervical cytology and cervical intraepithelial neoplasia (CIN) grade 1 behave similarly, with the majority of both showing regression.

Although these studies have demonstrated the importance of HPV persistence in the development of precancer CIN-3, the timing from infection to evidence of CIN-3 varies from 1 to 10 years.

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Medscape uses cookies to customize the site based on the information we collect at registration.Cervical cytology screening programs are associated with a reduction in the incidence of and mortality from invasive squamous and non-squamous cancer.Given that infections with the human papillomavirus (HPV) can lead to cervical cancer, screening and diagnostic programs involving Papanicolaou smears (Pap test) and colposcopy are the standard of care in North America.Both cervix to anus and anus to cervix autoinoculation in the same woman appears to be quite common.Whether either site serves as a long-term reservoir is unknown.

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